Autophagy and intermittent fasting: the connection for cancer therapy?
نویسندگان
چکیده
منابع مشابه
Enhanced Therapeutic Efficacy in Cancer Patients by Short-term Fasting: The Autophagy Connection
Preclinical studies suggest that fasting prior to chemotherapy may be an effective strategy to protect patients against the adverse effects of chemo-toxicity. Fasting may also sensitize cancer cells to chemotherapy. It is further suggested that fasting may similarly augment the efficacy of oncolytic viral therapy. The primary mechanism mediating these beneficial effects is thought to relate to ...
متن کاملAutophagy and cancer therapy.
Although autophagy has been shown to have a clear role as a tumor suppressor mechanism, its role in cancer treatment is still controversial. Because autophagy is a survival pathway activated during nutrient deprivation and other stresses, it is reasonable to think that autophagy can function as a tumor cell survival mechanism activated after cancer treatment. Such a mechanism could be widely im...
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15 صفحه اولAutophagy in Cancer Therapy
Autophagy represents a catabolic program involved in the degradation of cellular components via lysosomes. It serves to mitigate cellular stress and to provide metabolic precursors especially upon starvation. Thereby, autophagy can support the survival of cancer cells. In addition, there is now convincing evidence showing that under certain conditions autophagy can also foster cell death. This ...
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ژورنال
عنوان ژورنال: Clinics
سال: 2018
ISSN: 1807-5932,1980-5322
DOI: 10.6061/clinics/2018/e814s